What virus is known to cause chronic disease without jaundice?

Hepatitis C is known to cause chronic infection that often goes unnoticed because it typically does not present with jaundice. This characteristic makes it particularly insidious, as many individuals might not experience any symptoms for years or even decades, yet the virus can still cause significant liver damage over time. Hepatitis C can lead to chronic liver disease, cirrhosis, and even liver cancer, often without the overt signs associated with liver dysfunction like jaundice.

In contrast, Hepatitis A generally leads to acute liver inflammation and is often characterized by jaundice, particularly in older adults. Hepatitis B can also lead to chronic illness, but it frequently presents with jaundice during the acute phase and may have more noticeable symptoms. Human Immunodeficiency Virus (HIV) is not primarily associated with liver disease or jaundice; rather, it affects the immune system. Therefore, Hepatitis C stands out as the virus that can lead to chronic infection without the presence of jaundice.